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Alan P Fields Selected Research

Protein Kinases (Protein Kinase)

11/2021Protein kinase Cι and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities.
12/2020Protein kinase Cι promotes UBF1-ECT2 binding on ribosomal DNA to drive rRNA synthesis and transformed growth of non-small-cell lung cancer cells.
1/2020Oncogenic protein kinase Cι signaling mechanisms in lung cancer: Implications for improved therapeutic strategies.
12/2019Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma.
12/2019Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma.
1/2018Protein kinase Cι: A versatile oncogene in the lung.
1/2017Targeting oncogenic protein kinase Cι for treatment of mutant KRAS LADC.
3/2016Protein Kinase Cι Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung Adenocarcinoma.
2/2015Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia.
12/2013PKCι maintains a tumor-initiating cell phenotype that is required for ovarian tumorigenesis.
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Alan P Fields Research Topics

Disease

34Neoplasms (Cancer)
01/2022 - 01/2003
20Carcinogenesis
12/2020 - 06/2002
11Lung Neoplasms (Lung Cancer)
02/2022 - 09/2005
10Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
12/2020 - 09/2005
9Adenocarcinoma of Lung
12/2020 - 10/2005
6Neoplasm Metastasis (Metastasis)
06/2015 - 01/2011
6Pancreatic Neoplasms (Pancreatic Cancer)
06/2015 - 03/2010
6Colonic Neoplasms (Colon Cancer)
02/2009 - 06/2002
4Ovarian Neoplasms (Ovarian Cancer)
02/2022 - 11/2013
3Adenoma (Adenomas)
01/2022 - 01/2003
2Colorectal Neoplasms (Colorectal Cancer)
01/2022 - 04/2013
2Tics (Tic)
01/2017 - 12/2013
2Inflammation (Inflammations)
08/2011 - 01/2003
2Rheumatoid Arthritis
07/2008 - 02/2006
2BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
08/2004 - 03/2004
1Pancreatitis
02/2022
1Glioblastoma (Glioblastoma Multiforme)
11/2021
1Pain (Aches)
01/2017
1Acute Pain
01/2017
1Breast Neoplasms (Breast Cancer)
05/2016
1Basal Cell Carcinoma (Rodent Ulcer)
02/2015
1Medulloblastoma
02/2015
1Ewing Sarcoma (Sarcoma, Ewing)
03/2013
1Vascular Remodeling
05/2012
1Glucose Intolerance
04/2012
1Abdominal Obesity
04/2012
1Hyperinsulinism (Hyperinsulinemia)
04/2012
1Hypercholesterolemia
04/2012
1Obesity
04/2012
1Hypertriglyceridemia
04/2012
1Type 2 Diabetes Mellitus (MODY)
04/2012
1Metabolic Syndrome (Dysmetabolic Syndrome X)
04/2012
1Metaplasia
01/2012
1Colitis
08/2011

Drug/Important Bio-Agent (IBA)

20Protein Kinases (Protein Kinase)IBA
11/2021 - 03/2004
12Protein Kinase CIBA
01/2017 - 06/2002
11protein kinase C lambdaIBA
02/2022 - 10/2005
6Gold Sodium Thiomalate (Sodium Aurothiomalate)IBA
06/2015 - 02/2006
6IsoenzymesIBA
03/2014 - 01/2003
5Proteins (Proteins, Gene)FDA Link
01/2022 - 03/2003
5Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)IBA
12/2020 - 01/2010
4Messenger RNA (mRNA)IBA
01/2022 - 01/2003
4Auranofin (Ridaura)FDA Link
11/2021 - 12/2013
4AzoxymethaneIBA
02/2009 - 10/2004
3Ribosomal DNA (rDNA)IBA
01/2022 - 01/2017
3Pharmaceutical PreparationsIBA
11/2021 - 06/2007
3CateninsIBA
12/2020 - 12/2019
3rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA
12/2020 - 03/2011
3Biomarkers (Surrogate Marker)IBA
12/2020 - 01/2003
3GoldIBA
01/2017 - 02/2006
3Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
12/2013 - 10/2004
3CarcinogensIBA
01/2013 - 03/2004
3Matrix Metalloproteinases (MMPs)IBA
07/2012 - 01/2011
3Matrix Metalloproteinase 10 (Stromelysin 2)IBA
05/2012 - 01/2011
3Phosphotransferases (Kinase)IBA
04/2012 - 03/2004
3EnzymesIBA
06/2007 - 09/2005
2GTP Phosphohydrolases (GTPases)IBA
10/2020 - 11/2010
2RNA (Ribonucleic Acid)IBA
01/2019 - 01/2012
2Paclitaxel (Taxol)FDA LinkGeneric
01/2017 - 03/2004
2Oncogene Proteins (Oncogene Protein)IBA
04/2013 - 08/2004
2beta CateninIBA
02/2009 - 01/2009
2PPAR gammaIBA
09/2008 - 08/2007
2Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
06/2007 - 03/2004
2Cyclooxygenase 2 (Cyclooxygenase-2)IBA
03/2003 - 01/2003
2Transforming Growth Factor beta (TGF-beta)IBA
03/2003 - 06/2002
2Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA
03/2003 - 06/2002
1CeruletideIBA
02/2022
1Guanine NucleotidesIBA
01/2022
1transcription factor UBFIBA
12/2020
1Transcription Factors (Transcription Factor)IBA
12/2020
1SaltsIBA
01/2017
1LigandsIBA
05/2016
1PKC-3 proteinIBA
06/2015
1ErbB Receptors (EGF Receptor)IBA
02/2015
1Epidermal Growth Factor (EGF)IBA
02/2015
1glasdegibIBA
02/2015
1HhAntag691IBA
02/2015
1IPI-926IBA
02/2015
1sonidegibIBA
02/2015
1LY2940680IBA
02/2015
1BMS-833923IBA
02/2015
1Protein Kinase InhibitorsIBA
03/2014
1Transforming Growth Factors (Transforming Growth Factor)IBA
04/2013
1JNK Mitogen-Activated Protein KinasesIBA
03/2013
1STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA
01/2013
1protein kinase C zetaIBA
01/2013
1Metalloproteases (Metalloproteinases)IBA
05/2012
1CarbohydratesIBA
04/2012
1LipidsIBA
04/2012
1Insulin (Novolin)FDA Link
04/2012
1Glucose (Dextrose)FDA LinkGeneric
04/2012
1Protein Isoforms (Isoforms)IBA
01/2012
1NucleotidesIBA
01/2012
1Peptides (Polypeptides)IBA
08/2011
1Trefoil Factor-3IBA
08/2011
1sodium sulfate (sodium bisulfate)FDA LinkGeneric
08/2011
1Dextrans (Dextran)FDA Link
08/2011

Therapy/Procedure

8Therapeutics
02/2015 - 09/2005
5Drug Therapy (Chemotherapy)
06/2015 - 08/2004
1Radiotherapy
10/2013